Feb: Issue 151

Page 8 FOOD AND DRINK TRENDS IN 2020 – by Emma Berry
1 Waitrose (2019). Food and Drink Report 2019-2020. Online. Available at: www.waitrose.com/foodreport?source=aff_awin&utm_source=Skimlinks&utm_medium=affiliates&utm_campaign=https%3A%2F%2Fwww.waitrose.com%2Ffoodreport&source=aff_awin&awc=3691_1573221147_c029d3469a45fc1955abb325860b7634. Accessed 23rd November 2019
2 Whole Foods Market (2019). Our Top 10 Food Trends for 2020. Online. Available at: www.wholefoodsmarket.com/top-10-food-trends-2020. Accessed 23rd November 2019
3 NHS (2018). Salt Nutrition. Online. Available at: www.nhs.uk/live-well/eat-well/salt-nutrition/. Accessed on 24th November 2019
4 Sharif MK, Ejaz R and Pasha I (2018). Chapter 11: Nutritional and Therapeutic Potential of Spices. Therapeutic, Probiotic, and Unconventional Foods. Academic Press, Pages 181-199, ISBN 9780128146255. https://doi.org/10.1016/B978-0-12-814625-5.00011-X
5 Seafish (2019). Protein consumption and recent trends in the UK. Online. Available at: www.seafish.org/media/Publications/Protein_consumption_march_2019.pdf. Accessed 24th November 2019
6 British Nutrition Foundation (2018). Beans, pulses, fish, eggs, meat and other proteins. Online. Available at: www.nutrition.org.uk/healthyliving/healthydiet/protein.html?start=2. Accessed 24th November 2019
7 British Nutrition Foundation (2017). Healthy eating for vegans and vegetarians. Online. Available at: www.nutrition.org.uk/healthyliving/helpingyoueatwell/veganandvegetarian.html?limit=1&start=17 Accessed 24th November 2019
8 Chai BC, van der Voort JR, Grofelnik K, Eliasdottir HG, Kloss I and Perez-Cueto JA (2019). Which Diet Has the Least Environmental Impact on Our Planet? A Systematic Review of Vegan, Vegetarian and Omnivorous Diets. Sustainability, 11(15), p4110
9 Oosterveer P (2015). Promoting sustainable palm oil: viewed from a global networks and flows perspective. Journal of Cleaner Production. 107, p146-153
10 World Wildlife Fund (2014). The Growth of Soy. Impacts and Solutions. Online. Available at: http://awsassets.wwfdk.panda.org/downloads/wwf_soy_report_final_jan_19.pdf. Accessed: 24th November 2019
11 Drink Aware (2019). Latest UK alcohol unit guidance. Online. Available at: www.drinkaware.co.uk/alcohol-facts/alcoholic-drinks-units/latest-uk-alcohol-unit-guidance/. Accessed 24th November 2019
12 Drink Aware (2019). Health Effects of Alcohol. Online. Available at: www.drinkaware.co.uk/alcohol-facts/health-effects-of-alcohol/. Accessed 24th November 2019
13 Jiang, T. Alan (2019). Health Benefits of Culinary Herbs and Spices. Publication date 1 March 2019. www.ingentaconnect.com/content/aoac/jaoac/2019/00000102/00000002/art00010
14 https://health.usnews.com/best-diet
15 www.dailymail.co.uk/femail/article-7796115/The-five-key-diet-trend-predictions-2020.html
16 www.independent.co.uk/life-style/food-and-drink/food-boost-health-new-year-detox-2020-apples-salmon-greens-grains-lentils-a9265746.html

Page 11 - SATURATED FAT AND HEALTH: FRIEND OR FOE? By Laury Sellem
1 Scientific Advisory Committee on Nutrition. SACN report on Saturated fats and health (2019). https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/814995/SACN_report_on_saturated_fat_and_health.pdf
2 Bates B et al (2019). National Diet and Nutrition Survey. Results from year 7 and 8 (combined) of the Rolling Programme (2014/2015 - 2015/2016). 160
3 Chowdhury R et al (2014). Association of dietary, circulating and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 160, 398-406
4 Bittman M (2014). Opinion: Butter Is Back. The New York Times
5 Malhotra A (2013). Saturated fat is not the major issue. BMJ 347
6 Siri-Tarino PW, Sun Q, Hu FB and Krauss RM (2010). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 91, 535-546
7 Jakobsen MU et al (2009). Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies123. Am J Clin Nutr 89, 1425-1432
8 Imamura F et al (2016). Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials. PLoS Med. 13, e1002087
9 Briggs MA, Petersen KS and Kris-Etherton PM (2017). Saturated Fatty Acids and Cardiovascular Disease: Replacements for Saturated Fat to Reduce Cardiovascular Risk. Healthcare (Basel) 5
10 Zong G et al (2016). Intake of individual saturated fatty acids and risk of coronary heart disease in US men and women: two prospective longitudinal cohort studies. BMJ 355
11 Ference BA et al (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J 38, 2459-2472
12 Griffin BA (2017). Serum low‐density lipoprotein as a dietary responsive biomarker of cardiovascular disease risk: Consensus and confusion. Nutr Bull, 42: 266-273. doi:10.1111/nbu.12282
13 Antoni R et al (2019). A dietary exchange model to study inter-individual variation in serum low-density lipoprotein cholesterol response to dietary saturated fat intake. Proceedings of the Nutrition Society 78
14 Guo J et al (2017). Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 32, 269-287

Page 15 - NUTRITION SUPPORT FOR ONCOLOGY by Clare Thompson

1 Dhanapal R, Saraswathi T and Govind RN (2011). Cancer cachexia. Journal of Oral and Maxillofacial Pathology : JOMFP, 15(3), 257-260. https://doi.org/10.4103/0973-029X.86670
2 Bennegård K, Edén E, Ekman L, Scherstén T and Lundholm K (1983). Metabolic response of whole body and peripheral tissues to enteral nutrition in weight-losing cancer and noncancer patients. Gastroenterology, 85(1), 92-99. Retrieved from www.ncbi.nlm.nih.gov/pubmed/6406291
3 Bosaeus I, Daneryd P, Svanberg E and Lundholm K (2001). Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients. International Journal of Cancer, 93(3), 380-383. https://doi.org/10.1002/ijc.1332
4 Warnold I, Lundholm K and Scherstén T (1978). Energy balance and body composition in cancer patients. Cancer Research, 38(6), 1801-1807. Retrieved from www.ncbi.nlm.nih.gov/pubmed/647689
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6 Hyltander A, Drott C, Körner U, Sandström R and Lundholm K (1991). Elevated energy expenditure in cancer patients with solid tumours. European Journal of Cancer (Oxford, England : 1990), 27(1), 9-15. https://doi.org/10.1016/0277-5379(91)90050-n
7 Merrick HW, Long CL, Grecos GP, Dennis RS and Blakemore WS (1988). Energy Requirements for Cancer Patients and the Effect of Total Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition, 12(1), 8-14. https://doi.org/10.1177/014860718801200108
8 Berteretche MV, Dalix AM, D’Ornano AMC, Bellisle F, Khayat D and Faurion A (2004). Decreased taste sensitivity in cancer patients under chemotherapy. Supportive Care in Cancer, 12(8), 571-576. https://doi.org/10.1007/s00520-004-0589-2
9 Lee JLC, Leong LP and Lim SL (2016). Nutrition intervention approaches to reduce malnutrition in oncology patients: a systematic review. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 24(1), 469-480. https://doi.org/10.1007/s00520-015-2958-4
10 Ryan AM, Power DG, Daly L, Cushen SJ, Ní Bhuachalla Ē and Prado CM (2016). Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later. The Proceedings of the Nutrition Society, 75(2), 199-211. https://doi.org/10.1017/S002966511500419X
11 Aoyagi T, Terracina KP, Raza A, Matsubara H and Takabe K (2015). Cancer cachexia, mechanism and treatment. World Journal of Gastrointestinal Oncology, 7(4), 17–29. https://doi.org/10.4251/wjgo.v7.i4.17
12 De Waele E, Mattens S, Honoré PM, Spapen H, De Grève J and Pen JJ (2015). Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial. Appetite, 91, 298-301. https://doi.org/10.1016/j.appet.2015.04.049
13 Del Fabbro E, Hui D, Dalal S, Dev R, Nooruddin ZI, Noorhuddin Z and Bruera E (2011). Clinical outcomes and contributors to weight loss in a cancer cachexia clinic. Journal of Palliative Medicine, 14(9), 1004-1008. https://doi.org/10.1089/jpm.2011.0098
14 Martin L, Senesse P, Gioulbasanis I, Antoun S, Bozzetti F, Deans C, Baracos VE (2015). Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss. Journal of Clinical Oncology, 33(1), 90-99. https://doi.org/10.1200/JCO.2014.56.1894
15 Arends J, Baracos V, Bertz H, Bozzetti F, Calder PC, Deutz NEP, Weimann A (2017). ESPEN expert group recommendations for action against cancer-related malnutrition. Clinical Nutrition, 36(5), 1187-1196. https://doi.org/10.1016/j.clnu.2017.06.017
16 Young VR (1977). Energy Metabolism and Requirements in the Cancer Patient. Cancer Research, 37(July), 2336-2347
17 Dempsey D and Mullen J (1985). Macronutrient requirements in the malnourished cancer patient. How much of what and why? Cancer, 55(S1), 290-294.
18 Reeves MM (2004). Estimating Patients ’ Energy Requirements : Cancer as a Case Study, (March)
19 Ravasco P, Monteiro-Grillo I, Vidal PM and Camilo ME (2005). Dietary counseling improves patient outcomes: a prospective randomised controlled trial in colorectal cancer patients undergoing radiotherapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 23(7), 1431-1438. https://doi.org/10.1200/JCO.2005.02.054
20 Ovesen L, Allingstrup L, Hannibal J, Mortensen EL and Hansen OP (1993). Effect of dietary counselling on food intake, body weight, response rate, survival and quality of life in cancer patients undergoing chemotherapy: a prospective, randomised study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 11(10), 2043-2049. https://doi.org/10.1200/JCO.1993.11.10.2043
21 Sarcev T, Secen N, Sabo A and Povazan D (2008). Influence of dexamethasone on appetite and body weight in lung cancer patients. Medicinski Pregled, 61(11-12), 571-575. https://doi.org/10.2298/mpns0812571s
22 Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL and Bort-Martí S (2013). Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD004310.pub3
23 Mantovani G, Maccio A, Massa E and Madeddu C (2001). Managing Cancer-Related Anorexia/Cachexia. Drugs, 61(4), 499-514. https://doi.org/10.2165/00003495-200161040-00004
24 Nagaya N, Kojima M and Kangawa K (2006). Ghrelin, a Novel Growth Hormonereleasing Peptide, in the Treatment of Cardiopulmonary-associated Cachexia. Internal Medicine, 45(3), 127-134. https://doi.org/10.2169/internalmedicine.45.1402
25 Cannabis-In-Cachexia-Study-Group. Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Cerny T (2006). Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomised, double-blind, placebo-controlled clinical trial from the Cannabi. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 24(21), 3394-3400. https://doi.org/10.1200/JCO.2005.05.1847
26 Scarlett JM and Marks DL (2005). The use of melanocortin antagonists in cachexia of chronic disease. Expert Opinion on Investigational Drugs, 14(10), 1233-1239. https://doi.org/10.1517/13543784.14.10.1233
27 Fleming KA, Ericson MD, Freeman KT, Adank DN, Lunzer MM, Wilber SL and Haskell-Luevano C (2018). Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mic. ACS Chemical Neuroscience, 9(5), 1141-1151. https://doi.org/10.1021/acschemneuro.7b00495
28 Gordon JN, Trebble TM, Ellis RD, Duncan HD, Johns T and Goggin PM (2005). Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial. Gut, 54(4), 540-545. https://doi.org/10.1136/gut.2004.047563
29 Jatoi A, Dakhil SR, Nguyen PL, Sloan JA, Kugler JW, Rowland KM, Loprinzi CL (2007). A placebo-controlled double blind trial of etanercept for the cancer anorexia/weight loss syndrome. Cancer, 110(6), 1396-1403. https://doi.org/10.1002/cncr.22944
30 Riechelmann RP, Burman D, Tannock IF, Rodin G and Zimmermann C (2010). Phase II trial of mirtazapine for cancer-related cachexia and anorexia. The American Journal of Hospice & Palliative Care, 27(2), 106-110. https://doi.org/10.1177/1049909109345685
31 Naing A, Dalal S, Abdelrahim M, Wheler J, Hess K, Fu S, Kurzrock R (2015). Olanzapine for cachexia in patients with advanced cancer: an exploratory study of effects on weight and metabolic cytokines. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 23(9), 2649-2654. https://doi.org/10.1007/s00520-015-2625-9
32 Topkan E, Yavuz MN, Onal C and Yavuz AA (2009). Prevention of acute radiation-induced esophagitis with glutamine in non-small cell lung cancer patients treated with radiotherapy: evaluation of clinical and dosimetric parameters. Lung Cancer (Amsterdam, Netherlands), 63(3), 393-399. https://doi.org/10.1016/j.lungcan.2008.06.015
33 Kraft M, Kraft K, Gärtner S, Mayerle J, Simon P, Weber E, Lerch MM (2012). L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomised multicentre trial. Nutrition Journal, 11, 52. https://doi.org/10.1186/1475-2891-11-52
34 May PE, Barber A, D’Olimpio JT, Hourihane A and Abumrad NN (2002). Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine and glutamine. American Journal of Surgery, 183(4), 471-479. https://doi.org/10.1016/s0002-9610(02)00823-1
35 Engelen MP, Safar AM, Bartter T, Koeman F and Deutz NEP (2015). High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 26(9), 1960-1966. https://doi.org/10.1093/annonc/mdv271
36 Camargo C de Q, Mocellin MC, Pastore Silva J de A, Fabre ME de S, Nunes EA and Trindade EBS de M (2016). Fish oil supplementation during chemotherapy increases posterior time to tumor progression in colorectal cancer. Nutrition and Cancer, 68(1), 70-76. https://doi.org/10.1080/01635581.2016.1115097
37 Paixão EM da S, Oliveira AC de M, Pizato N, Muniz-Junqueira MI, Magalhães KG, Nakano EY and Ito MK (2017). The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomised double-blind controlled trial. Nutrition Journal, 16(1), 71. https://doi.org/10.1186/s12937-017-0295-9
38 Sánchez-Lara K, Turcott JG, Juárez-Hernández E, Nuñez-Valencia C, Villanueva G, Guevara P and Arrieta O (2014). Effects of an oral nutritional supplement containing eicosapentaenoic acid on nutritional and clinical outcomes in patients with advanced non-small cell lung cancer: randomised trial. Clinical Nutrition (Edinburgh, Scotland), 33(6), 1017-1023. https://doi.org/10.1016/j.clnu.2014.03.006

Page 19 CANCER AND KETO - Joanna Injore
1 Harris KA (1998). The informational needs of patients with cancer and their families. Cancer Practice 6(1) 39-46
2 Sremanakova J, Sowerbutts AM, Burden S (2018). A systematic review of the use of ketogenic diets in adult patients with cancer. J Hum Nutr Diet. 31, 793-802
3 Erickson N, Boscheri A, Linke B et al (2017). Systematic review: isocaloric ketogenic dietary regimes for cancer patients. Med Oncol 34, 72
4 Klepper J and Leiendecker B (2013). Glut1 Deficiency Syndrome and Novel Ketogenic Diets. Journal of Child Neurology, 28(8), 1045-1048
5 Sofou K, Dahlin M, Hallböök T, Lindefeldt M, Viggedal G, Darin N (2017). Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes. J Inherit Metab Dis. 40(2): 237-245
6 Allen BG, Bhatia SK, Anderson CM et al (2014). Ketogenic diets as an adjuvant cancer therapy: history and potential mechanism. Redox Biol 2, 963-970
7 Liberti MV, Locasale JW (2016). The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci.;41(3): 211-218
8 Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B (2019). Ketogenic diet in the treatment of cancer – Where do we stand? [Online]. Molecular Metabolism [Accessed 04 December 2019]. Available at https://doi.org/10.1016/j.molmet.2019.06.026
9 Schroeder U, Himpe B, Pries R et al (2013). Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. Nutrition and Cancer. 65: 843-9
10 Cohen CW, Fontaine KR, Arend RC, Soleymani T, Gower BA (2018). Favorable effects of a ketogenic diet on physical function, perceived energy and food cravings in women with ovarian or endometrial cancer: a randomised, controlled trial. Nutrients 10:1187
11 Cohen CW, Fontaine KR, Arend RC, Alvarez RD, Leath III CA, Huh WA, Bevis KS Kim KH, Straughn JM, Gower BA (2018). A Ketogenic Diet Reduces Central Obesity and Serum Insulin in Women with Ovarian or Endometrial Cancer, The Journal of Nutrition; 148; (8):1253-1260
12 Erickson N, Boscheri A, Linke B et al (2017). Systematic review: isocaloric ketogenic dietary regimes for cancer patients. Med Oncol 34, 72

Page 22 - SPOTLIGHT ON… FOOD ACTIVE by Beth Bradshaw
1 https://files.digital.nhs.uk/5B/B1297D/HSE%20report%20summary.pdf
2 https://app.box.com/s/hbddn16digjdhs24ocha6u40x9j9xsqh
3 www.gov.uk/government/publications/health-matters-obesity-and-the-food-environment/health-matters-obesity-and-the-food-environment--2
4 https://digital.nhs.uk/data-and-information/publications/statistical/statistics-on-obesity-physical-activity-and-diet/statistics-on-obesity-physical-activity-and-diet-england-2019/part-4-childhood-obesity
5 www.bps.org.uk/sites/bps.org.uk/files/Policy/Policy%20-%20Files/Psychological%20Perspectives%20on%20Obesity%20-%20Addressing%20Policy%2C%20Practice%2C%20and%20Research%20Priorities.pdf
6 www.foodactive.org.uk/projects/local-authority-declaration/
7 www.giveuplovingpop.org.uk/
8 www.gov.uk/government/consultations/advancing-our-health-prevention-in-the-2020s/advancing-our-health-prevention-in-the-2020s-consultation-document
9 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/832182/Sugar_reduction__Yr2_progress_report.pdf
10 http://obesityhealthalliance.org.uk/wp-content/uploads/2017/11/A-Watershed-Moment-report.pdf
11 www.foodactive.org.uk/wp-content/uploads/2019/02/Food-Active-Price-Promotions-on-Less-Healthy-Food-and-Drink.pdf
12 http://obesityhealthalliance.org.uk/wp-content/uploads/2018/11/Out-of-Place-Obesity-Health-Alliance-2.pdf
13 www.foodactive.org.uk/wp-content/uploads/2019/03/Strand-1-High-Street-Food-Placement-Project-Strand-One-Final-Report-March-20191.pdf

Page 26 OBESITY AND ENERGY METABOLISM – MicrObesity – by Bogna Nicinska

1 World Health Organisation (WHO) Obesity and overweight. Fact sheet (2017)
2 Romieu L, Dossus S, Barquera HM, Blottière PW, Franks M, Gunter et al. IARC working group on Energy Balance and Obesity, Energy balance and obesity: what are the main drivers? Cancer Causes Control, 28 (2017), p247-258
3 Dobell C. The discovery of the intestinal protozoa of man. Proceedings of the Royal Society of Medicine. 1920;13 (Sect_Hist_Med): 1-15
4 Alimentary Pharmabiotic Centre (2017)
5 Mulders RJ, de Git KCG, Schéle E, Dickson SL, Sanz Y, Adan RAH (2018). Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems. Obesity Reviews, 19(4), 435-451. doi:10.1111/obr.12661
6 Niccolai E, Boem F, Russo E and Amedei A (2019). The Gut–Brain Axis in the Neuropsychological Disease Model of Obesity: A Classical Movie Revised by the Emerging Director ‘Microbiome.’ Nutrients, 11(1), 156. doi:10.3390/nu11010156
7 OUP accepted manuscript. (2018). Advances in Nutrition: An International Review Journal. doi:10.1093/advances/nmy078
8 Vallianou N, Stratigou T, Christodoulatos GS, Dalamaga M (2019). Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives. Current Obesity Reports. doi:10.1007/s13679-019-00352-2
9 EP Nyangale, DS Mottram, GR Gibson. Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res, 11 (2012), p5573-5585
10 Gensollen T, Iyer SS, Kasper DL, Blumberg RS. How colonization by microbiota in early life shapes the immune system. Science 2016, 352, 539-544
11 Natividad JMM, Verdu EF. Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications. Pharmacol. Res. 2013, 69, 42-51
12 den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota and host energy metabolism. J Lipid Res. 2013, 54, 2325-2340
13 Bäumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature 2016, 535, 85-93
14 Rowland I, Gibson G, Heinken A, Scott K, Swann J, Thiele I, Tuohy K. Gut microbiota functions: Metabolism of nutrients and other food components. Eur J Nutr. 2018, 57, 1-24
15 EP Nyangale, DS Mottram, GR Gibson. Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res, 11 (2012), p5573-5585
16 Bercik P, Denou E, Collins J, Jackson W, Lu J, Jury J, Deng Y, Blennerhassett P, Macri J, McCoy KD et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 2011;141(2): 599-609
17 Anitha M, Reichardt F, Tabatabavakili S, Nezami BG, Chassaing B, Mwangi S et al. Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice. Cell Mol Gastroenterol Hepatol. 2016; 2(3): 328-39. https://doi.org/10. 1016/j.jcmgh.2015.12.008
18 Reichardt F, Chassaing B, Nezami BG, Li G, Tabatabavakili S, Mwangi S et al. Western diet induces colonic nitrergic myenteric neuropathy and dysmotility in mice via saturated fatty acid and lipopolysaccharide induced TLR4 signalling. J Physiol. 2017; 595(5): 1831-46. https://doi.org/10.1113/JP273269
19 Fayfman M, Flint K and Srinivasan S (2019). Obesity, Motility, Diet and Intestinal Microbiota – Connecting the Dots. Current Gastroenterology Reports, 21(4)
20 MJ Khan, K Gerasimidis, CA Edwards, MG Shaikh Role of gut microbiota in aetiology of obesity: proposed mechanisms and review of literature. J Obes (2016), p73536 Epub 2016
21 Cano PG, Santacruz A, Trejo FM, Sanz Y. Bifidobacterium CECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet-fed mice. Obesity (Silver Spring) 2013; 21(11): 2310-21
22 Delzenne NM, Neyrinck AM, Bäckhed F, Cani PD. Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 2011; 7: 639-646
23 Etxeberria U, Arias N, Boqué N, Romo-Hualde A, Macarulla MT, Portillo MP, Milagro FI, Martínez JA. Metabolic faecal fingerprinting of trans-resveratrol and quercetin following a high-fat sucrose dietary model using liquid chromatography coupled to high-resolution mass spectrometry. Food Funct 2015; 6(8): 2758-67
24 Allegretti JR, Kassam Z, Mullish BH, Chiang A, Carrellas M, Hurtado J. Thompson C (2019). Effects of Fecal Microbiota Transplantation with Oral Capsules in Obese Patients. Clinical Gastroenterology and Hepatology. doi:10.1016/j.cgh.2019.07.006
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28 Source: Gerard Clarke, Kiran V Sandhu, Brendan T Griffin, Timothy G Dinan, John F Cryan and Niall P Hyland. Pharmacological Reviews. April 1, 2019, 71 (2) 198-224; DOI: https://doi.org/10.1124/pr.118.015768

Page 30 - DIET, FERTILITY AND IVF by Dr Mabel Blades
1 Human Fertilisation & Embryology Authority (2019). Fertility treatment 2017: trends and figures. May 2019
2 Dag ZO and Dilbaz B (2015). Impact of obesity on infertility in women. Turkish-German Gynaecological Association.16 (2) p111-117
3 NICE( 2010). Weight management before, during and after pregnancy. July 2010
4 Chavarro JE et al (2010). Body Mass Index in relation to semen quality, sperm DNA integrity and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. May 1:93 (7)2222-31
5 NICE (2014). Vitamin D: increasing supplementation in at risk groups
6 Silva P (2016). MS risk linked to mothers with vitamin D deficiency in first trimester of pregnancy. March 8th, Multiple Sclerosis News Today
7 The UK Iodine Group (2019). Iodine in pregnancy and lactation (breastfeeding)
8 Falliah A et al (2018). Zinc an essential element in male fertility: A review of Zinc in men’s health
9 Lass A and Belluzzi A (2019). Omega-3 polyunsaturated fatty acids and IVF treatment. RBMO. Vol 38 issue 1
10 NHS information (2019). Planning your pregnancy. Accessed 31st Dec 19
11 Brooke V et al (2011). Effect of alcohol consumption on in vitro fertilisation. Obstet Gynecol. Jan 117(10 136-142)

Page 33 - AN MDT APPROACH TO COMPLEX FEEDING DIFFICULTIES IN CHILDREN – by Lucy Upton, Lucy Bates, Karen Sheffield.
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Page 38 - FUSSY EATING IN TODDLERS – by Sarah Lindsay Brown

1 Taylor CM and Emmett PM (2019). Picky eating in children: causes and consequences. Proc Nutr Soc 78, 161-169
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3 Levene IR and Williams A (2018). Fifteen-minute consultation: The healthy child: ‘My child is a fussy eater!’ Arch Dis Child Educ Pract Ed 103, 71-78
4 Zimmerman J and Fisher M (2017). Avoidant/Restrictive Food Intake Disorder (ARFID). Curr Probl Pediatr Adolesc Health Care 47, 95-103
5 Taylor CM, Wernimont SM, Northstone K and Emmett PM (2015). Picky/fussy eating in children: Review of definitions, assessment, prevalence and dietary intakes. Appetite 95, 349-359
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7 Smith AD et al (2017). Food fussiness and food neophobia share a common etiology in early childhood. J Child Psychol Psychiatry 58, 189-196.
8 Bell KI and Tepper BJ (2006). Short-term vegetable intake by young children classified by 6-n-propylthoiuracil bitter-taste phenotype. Am. J. Clin. Nutr. 84, 245-251
9 Fildes A et al (2014). Nature and nurture in children’s food preferences. Am. J. Clin. Nutr. 99, 911-917
10 Taylor CM, Northstone K, Wernimont SM and Emmett PM (2016). Macro- and micronutrient intakes in picky eaters: a cause for concern? Am. J. Clin. Nutr. 104, 1647-1656.
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Page 42 TECHNOLOGY: Transforming working lives – by Evelyn Newman
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Page 44 POLYCYSTIC OVARY SYNDROME (PCOS) AND SYMPTOM MANAGEMENT – by Alex Ballard
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Page 47 - ORAL NUTRITIONAL SUPPORT IN EATING DISORDERS – by Alexia Dempsey

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Page 51 - DOES GREEN TEA LIVE UP TO THE HYPE? By Maeve Hanan

1 Varnam and Sutherland. Beverages: Technology, Chemistry and Microbiology. Springer (1994)
2 Khan and Mukhtar (2007). Tea polyphenols for health promotion. www.sciencedirect.com/science/article/pii/S0024320507004717
3 NHS Choices. Green tea: the elixir of life or just hype? Accessed March 2018 via: www.nhs.uk/Livewell/superfoods/Pages/is-green-tea-a-superfood.aspx
4 Rains et al. (2011). Anti-obesity effects of green tea catechins: a mechanistic review. www.ncbi.nlm.nih.gov/pubmed/21115335
5 Vuong (2012). Improved extraction of green tea components from teabags using the microwave oven. www.sciencedirect.com/science/article/pii/S0889157512000828
6 Zheng et al (2012). Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomised controlled trials. www.ncbi.nlm.nih.gov/pubmed/21715508
7 Khalesi et al (2014). Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. https://link.springer.com/article/10.1007/s00394-014-0720-1
8 Arab et al (2012). Green and black tea consumption and risk of stroke: a meta-analysis.www.ncbi.nlm.nih.gov/pubmed/19228856>
9 Wang et al (2012). Black and green tea consumption and the risk of coronary artery disease: a meta-analysis. www.ncbi.nlm.nih.gov/pubmed/21248184
10 Polychronopoulos et al (2012). Effects of black and green tea consumption on blood glucose levels in non-obese elderly men and women from Mediterranean Islands (MEDIS epidemiological study). www.ncbi.nlm.nih.gov/pubmed/18204918
11 Odegaard et al (2008). Coffee, tea and incident Type 2 diabetes: the Singapore Chinese Health Study. www.ncbi.nlm.nih.gov/pubmed/18842784
12 Wolfram et al (2006). Anti-obesity effects of green tea: from bedside to bench. www.ncbi.nlm.nih.gov/pubmed/16470636
13 Jurgens et al (2012). Green tea for weight loss and weight maintenance in overweight or obese adults. www.ncbi.nlm.nih.gov/pubmed/23235664
14 Hursel et al (2009). The effects of green tea on weight loss and weight maintenance: a meta-analysis. www.ncbi.nlm.nih.gov/pubmed/19597519
15 Phung et al (2010). Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. www.ncbi.nlm.nih.gov/pubmed/19906797
16 Boehm et al (2009). Green tea (Camellia sinensis) for the prevention of cancer. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005004.pub2/abstract
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19 Shen et al (2009). Green tea and bone metabolism. www.ncbi.nlm.nih.gov/pubmed/19700031
20 Spiro and Lockyer (2018). Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?. https://onlinelibrary.wiley.com/doi/full/10.1111/nbu.12304
21 Heinrich et al (2011). Green tea polyphenols provide photo-protection, increase microcirculation, and modulate skin properties of women.
22 Janjua et al (2009). A two-year, double-blind, randomised placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photo-aging skin
23 Chiu et al (2005). Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photo-aging skin
24 Yin et al (2015). The effect of green tea intake on risk of liver disease: a meta analysis. www.ncbi.nlm.nih.gov/pmc/articles/PMC4538013/
25 Holbrook et al (2005). Systematic overview of warfarin and its drug and food interactions. www.ncbi.nlm.nih.gov/pubmed/15911722
26 Kamao et al (2007). Vitamin K content of foods and dietary vitamin K intake in Japanese young women. www.ncbi.nlm.nih.gov/pubmed/18202532
27 Samman et al (2001). Green tea or rosemary extract added to foods reduces non-haem-iron absorption. www.ncbi.nlm.nih.gov/pubmed/11237939
28 BBC Website. The food supplement that ruined my liver (25/10/18). www.bbc.com/news/stories-45971416
29 Mazzanti et al (2015). Hepatotoxicity of green tea: an update. www.ncbi.nlm.nih.gov/pubmed/25975988
30 EFSA (2018). EFSA assesses safety of green tea catechins. www.efsa.europa.eu/en/press/news/180418